Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.56 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 4/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497138 | 1.00 | KLK5 (0.57) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL7452177 | 1.00 | KLK5 (0.57) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL5926274 | 0.94 | CTSS (0.57) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL27331529 | 0.88 | CTSS (0.56) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL30841329 | 0.88 | CTSK (0.57) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL27330377 | 0.88 | CTSK (0.57) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL7283706 | 0.85 | KLK5 (0.59) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL27330766 | 0.85 | MMP1 (0.54) | KLK5CTSSCTSKPOLBIDO1 | |
| SCHEMBL7455378 | 0.84 | ITGA4 (0.45) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL6292728 | 0.84 | KLK5 (0.72) | KLK5CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1127488-C | Compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 2003-11-12 | — | — | CN | disclosed |
| EP-0907643-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| US-5919777-A | PIPERAZINE DERIVATIVES USEFUL FOR TREATING MEDICAL DISORDERS RESULTING FROM A GROWTH HORMONE DEFIENCY | NOVO NORDISK A/S (DK) | 1999-07-06 | — | — | US | disclosed |
| CN-1216537-A | Compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 1999-05-12 | — | — | CN | disclosed |
| EP-0907643-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997040023-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | disclosed |