Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839515 | 0.91 | KDM4E (0.46) | SIRT2KDM4EALDH1A1POLBGAA | |
| SCHEMBL8347758 | 0.84 | SIRT2 (0.55) | SIRT2ALDH1A1LMNA | |
| SCHEMBL8364700 | 0.83 | SIRT2 (0.55) | SIRT2ALDH1A1LMNA | |
| SCHEMBL29455876 | 0.74 | SIRT2 (0.63) | SIRT2POLB | |
| SCHEMBL2000374 | 0.73 | SIRT2 (0.61) | SIRT2ALDH1A1 | |
| SCHEMBL22356512 | 0.73 | SIRT2 (0.61) | SIRT2ALDH1A1 | |
| SCHEMBL1504961 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1POLBGAALMNA | |
| SCHEMBL523065 | 0.72 | SIRT2 (0.60) | SIRT2 | |
| SCHEMBL1999739 | 0.72 | SIRT2 (0.60) | SIRT2 | |
| SCHEMBL522051 | 0.72 | SIRT2 (0.60) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |