Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264411 | 0.83 | MAOB (0.44) | MAOBABCB1PDE2AMAPTHTT | |
| SCHEMBL8265170 | 0.83 | MAOB (0.48) | MAOBABCB1PDE2AMAPTHTT | |
| SCHEMBL91372 | 0.82 | MAOB (0.43) | MAOBABCB1PDE2AMAPTHTT | |
| SCHEMBL78450 | 0.81 | MAOB (0.43) | MAOBABCB1PDE2AMAPTHTT | |
| SCHEMBL8262885 | 0.80 | ENPP2 (0.47) | MAOBABCB1PDE2AAPPPIK3CD | |
| SCHEMBL1563576 | 0.78 | GABRA5 (0.55) | MAOBGRM5GABRA5MAPTHTT | |
| SCHEMBL27383565 | 0.78 | IDO1 (0.51) | MAOBGRM5GABRA5MAPT | |
| SCHEMBL24265294 | 0.76 | GABRA5 (0.46) | ABCB1GRM5GABRA5 | |
| SCHEMBL23920187 | 0.74 | GABRA5 (0.45) | MAOBGRM5GABRA5 | |
| SCHEMBL8288265 | 0.74 | KCNH2 (0.49) | MAOBGRM5MAPTSMN1; SMN2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |