Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376330 | 0.84 | ALDH1A1 (0.38) | SLC6A4HRH3 | |
| SCHEMBL8006237 | 0.80 | OPRL1 (0.33) | HTR2BHTR1AOPRL1 | |
| SCHEMBL18509004 | 0.76 | ALDH1A1 (0.34) | SLC6A4HRH3 | |
| SCHEMBL7999343 | 0.76 | CYP2D6 (0.32) | — | |
| SCHEMBL8265470 | 0.75 | L3MBTL1 (0.37) | FPR1FPR2L3MBTL1TP53KMO | |
| SCHEMBL18508711 | 0.73 | HTR6 (0.34) | HTR2AHTR2CHTR2BFPR1FPR2 | |
| SCHEMBL13168870 | 0.69 | ALDH1A1 (0.38) | SLC6A4HRH3L3MBTL1CARM1PRMT6 | |
| SCHEMBL8264212 | 0.68 | L3MBTL1 (0.35) | FPR1FPR2L3MBTL1HTR6TP53 | |
| SCHEMBL8250365 | 0.68 | CYP2C9 (0.37) | — | |
| SCHEMBL13168707 | 0.68 | ITK (0.41) | HRH3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |