Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 10/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665023 | 0.76 | TYMS (0.44) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL7709612 | 0.76 | TYMS (0.51) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL4084412 | 0.76 | TYMS (0.44) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL30582767 | 0.73 | MEN1 (0.65) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL1892650 | 0.73 | MEN1 (0.65) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL9079255 | 0.72 | TYMS (0.47) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL30211961 | 0.71 | TYMS (0.51) | MEN1KMT2ATYMSALDH1A1CYP3A4 | |
| SCHEMBL7709761 | 0.70 | ALDH1A1 (0.60) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL9338559 | 0.70 | PDE7A (0.39) | MEN1NPC1RAB9AKMT2ATYMS | |
| SCHEMBL29099269 | 0.70 | TYMS (0.50) | MEN1NPC1RAB9AKMT2ATYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2011-06-02 | — | — | US | disclosed |
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2011-06-02 | — | — | US | disclosed |
| WO-2009135890-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | POLRMT, DDX1, DDX18 | MEN1 4426/4885NPC1 1729/4885RAB9A 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.