Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 10/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665023 | 1.00 | TYMS (0.44) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7709612 | 0.82 | TYMS (0.51) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL28008397 | 0.81 | NPSR1 (0.47) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL30582767 | 0.80 | MEN1 (0.65) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1892650 | 0.80 | MEN1 (0.65) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1133994 | 0.79 | TYMS (0.44) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9079255 | 0.78 | TYMS (0.47) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7703726 | 0.77 | S100A4 (0.44) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7709761 | 0.76 | ALDH1A1 (0.60) | TYMSMEN1NPC1RAB9AKMT2A | |
| SCHEMBL13618356 | 0.76 | MEN1 (0.39) | TYMSMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110283163-B | 4-tert-butyloxycarbonylpiperazine-3-nitro-1, 8-naphthalimide derivative and synthetic method and application thereof | 桂林医学院 | 2023-03-14 | — | — | CN | claimed |
| CN-110194741-B | 4-benzoyl piperazine-3-nitro-1, 8-naphthalimide derivative and preparation method and application thereof | 桂林医学院 | 2022-09-09 | — | — | CN | claimed |
| CN-110283123-B | 4-p-toluenesulfonyl piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof | 桂林医学院 | 2022-06-17 | — | — | CN | claimed |
| CN-110272388-B | 4-dithioformic acid piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof | 桂林医学院 | 2022-06-17 | — | — | CN | claimed |
| CN-110283163-B | 4-tert-butyloxycarbonylpiperazine-3-nitro-1, 8-naphthalimide derivative and synthetic method and application thereof | 桂林医学院 | 2023-03-14 | — | — | CN | disclosed |
| CN-110283163-B | 4-tert-butyloxycarbonylpiperazine-3-nitro-1, 8-naphthalimide derivative and synthetic method and application thereof | 桂林医学院 | 2023-03-14 | — | — | CN | disclosed |
| CN-110194741-B | 4-benzoyl piperazine-3-nitro-1, 8-naphthalimide derivative and preparation method and application thereof | 桂林医学院 | 2022-09-09 | — | — | CN | disclosed |
| CN-110194741-B | 4-benzoyl piperazine-3-nitro-1, 8-naphthalimide derivative and preparation method and application thereof | 桂林医学院 | 2022-09-09 | — | — | CN | disclosed |
| CN-114702509-A | Benzothienonaphthalimide derivative and synthesis process and application thereof | 浙江工业大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-110283123-B | 4-p-toluenesulfonyl piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof | 桂林医学院 | 2022-06-17 | — | — | CN | disclosed |
| CN-110272388-B | 4-dithioformic acid piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof | 桂林医学院 | 2022-06-17 | — | — | CN | disclosed |
| CN-110317171-B | 4-dithioformic acid piperazine-1, 8-naphthalimide derivative and preparation method and application thereof | 桂林医学院 | 2022-06-17 | — | — | CN | disclosed |
| US-20090247524-A1 | HSP90 Inhibitor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-10-01 | — | — | US | disclosed |
| US-20090247524-A1 | HSP90 Inhibitor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-10-01 | — | — | US | disclosed |
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| EP-2036895-A1 | HSP90 INHIBITOR | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-03-18 | — | — | EP | disclosed |
| EP-2036895-A1 | HSP90 INHIBITOR | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-03-18 | — | — | EP | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE (CN) | 2006-05-25 | — | — | US | disclosed |
| EP-1626050-A1 | SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES | East China University of Science and Technology (CN) | 2006-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | HCCS, SQOR, MKI67 | TYMS 631/4885MEN1 3613/4885NPC1 3188/4885 |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | HCCS, SQOR, MKI67 | TYMS 631/4885MEN1 3613/4885NPC1 3188/4885 |
| US-20090247524-A1 | HSP90 Inhibitor | HSP90AB1, HSP90B1, HSP90AA1 | TYMS 3232/4885MEN1 4381/4885NPC1 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.