Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | GAA | P10253 | 5/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878 | 0.87 | CA12 (0.61) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 | |
| Dimethylamine SCHEMBL5809746 | 0.85 | SMN1; SMN2 (0.56) | MAPTGAASMN1; SMN2LMNAALDH1A1 | |
| Bromide SCHEMBL28187052 | 0.84 | IDO1 (0.58) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL266020 | 0.84 | IDO1 (0.58) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL49571 | 0.84 | RAB9A (0.55) | MAPTGAARAB9AL3MBTL1NPC1 | |
| SCHEMBL1459772 | 0.84 | MAPT (1.00) | MAPTGAARAB9AL3MBTL1NPC1 | |
| SCHEMBL39057 | 0.84 | MAPT (1.00) | MAPTGAARAB9AL3MBTL1NPC1 | |
| Dimethylamine SCHEMBL6440259 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1ALOX12HTT | |
| SCHEMBL8348682 | 0.82 | MAPT (0.72) | MAPTGAARAB9AL3MBTL1NPC1 | |
| Bromide SCHEMBL25274321 | 0.82 | IDO1 (0.56) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160139143-A1 | DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY | VENTANA MEDICAL SYSTEMS, INC. | 2016-05-19 | — | — | US | disclosed |
| EP-1401451-B1 | QUINAZOLINE DERIVATIVES WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |