Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023611 | 0.84 | POLB (0.55) | POLBTSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL10063079 | 0.80 | POLB (0.52) | POLBTSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL16992123 | 0.80 | CHRM4 (0.50) | POLBTSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL7094775 | 0.78 | POLB (0.76) | POLBTSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL9177983 | 0.78 | TSHR (0.47) | POLBTSHRALDH1A1KMT2ARECQL | |
| SCHEMBL908529 | 0.77 | MEN1 (0.59) | POLBTSHRALDH1A1CYP2C19KMT2A | |
| SCHEMBL17177194 | 0.77 | TSHR (0.48) | POLBTSHRALDH1A1KMT2ARECQL | |
| SCHEMBL24348071 | 0.74 | L3MBTL1 (0.49) | POLBTSHRALDH1A1RECQLLMNA | |
| SCHEMBL8188669 | 0.74 | TSHR (0.55) | POLBTSHRALDH1A1KMT2ARECQL | |
| SCHEMBL15531169 | 0.73 | KMT2A (0.44) | POLBTSHRALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140467-A1 | OXOBENZINDOLIZINOQUINOLINES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2009-11-19 | — | — | WO | disclosed |