Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10082578 | 0.86 | DGAT1 (0.51) | DGAT1KDM4EGLAALDH1A1MAP2K1 | |
| SCHEMBL7806435 | 0.81 | KDM5A (0.45) | KDM4EGLAALDH1A1KDM5AGAA | |
| SCHEMBL21666210 | 0.79 | ALDH1A1 (0.64) | DGAT1IRAK4KDM4EGLAALDH1A1 | |
| SCHEMBL21075953 | 0.78 | ALDH1A1 (0.43) | KDM4EGLAALDH1A1KDM5AGAA | |
| SCHEMBL22101252 | 0.78 | ALDH1A1 (0.43) | KDM4EALDH1A1KDM5AGAAAPEX1 | |
| SCHEMBL17540395 | 0.77 | DGAT1 (0.41) | DGAT1KDM4EALDH1A1MAP2K1KDM5A | |
| SCHEMBL27959043 | 0.76 | DGAT1 (0.47) | DGAT1IRAK4KDM4EGLAALDH1A1 | |
| SCHEMBL26170005 | 0.76 | ALDH1A1 (0.69) | DGAT1IRAK4KDM4EGLAALDH1A1 | |
| SCHEMBL13167870 | 0.74 | AAK1 (0.45) | KDM4EGLAALDH1A1KDM5AMAPT | |
| SCHEMBL2612359 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1GAAHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143049-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |