Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13618878 | 0.99 | HSD17B1 (0.52) | HSD17B1HSD17B2NPC1RAB9ATAS1R3 | |
| SCHEMBL13618899 | 0.98 | HSD17B1 (0.48) | HSD17B1HSD17B2NPC1RAB9ATAS1R3 | |
| SCHEMBL13618885 | 0.92 | HSD17B1 (0.48) | HSD17B1HSD17B2SMN1; SMN2UTS2RACKR3 | |
| SCHEMBL13618876 | 0.91 | HSD17B1 (0.49) | HSD17B1HSD17B2UTS2RACKR3KMT2A | |
| SCHEMBL13618880 | 0.83 | HSD17B1 (0.43) | HSD17B1HSD17B2NPC1RAB9ATAS1R3 | |
| SCHEMBL13618897 | 0.82 | NPC1 (0.61) | HSD17B1HSD17B2NPC1RAB9ATAS1R3 | |
| SCHEMBL13618872 | 0.82 | HSD17B1 (0.45) | HSD17B1HSD17B2NPC1RAB9ATAS1R3 | |
| SCHEMBL13618887 | 0.80 | HDAC1 (0.36) | NPC1RAB9ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL13618877 | 0.79 | HDAC1 (0.37) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13618883 | 0.75 | PDE2A (0.39) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | GRIA1, GRIN1, GLRA1 | HSD17B1 1172/4885HSD17B2 1612/4885NPC1 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.