Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LDLR | P01130 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13618885 | 0.99 | HSD17B1 (0.48) | HSD17B1HSD17B2POLBLDLRACKR3 | |
| SCHEMBL13618878 | 0.92 | HSD17B1 (0.52) | HSD17B1HSD17B2ACKR3UTS2RKMT2A | |
| SCHEMBL13618886 | 0.91 | HSD17B1 (0.50) | HSD17B1HSD17B2ACKR3UTS2RKMT2A | |
| SCHEMBL13618899 | 0.89 | HSD17B1 (0.48) | HSD17B1HSD17B2POLBACKR3UTS2R | |
| SCHEMBL13618872 | 0.84 | HSD17B1 (0.45) | HSD17B1HSD17B2ACKR3UTS2RKMT2A | |
| SCHEMBL13618880 | 0.82 | HSD17B1 (0.43) | HSD17B1HSD17B2ACKR3UTS2RKMT2A | |
| SCHEMBL13618895 | 0.82 | NPC1 (0.51) | POLBUTS2RLMNAKMT2AMEN1 | |
| SCHEMBL13618875 | 0.80 | LMNA (0.39) | POLBLDLRACKR3LMNAKMT2A | |
| SCHEMBL13618884 | 0.79 | LMNA (0.37) | POLBLDLRACKR3LMNAKMT2A | |
| SCHEMBL13618874 | 0.75 | PDE2A (0.38) | HSD17B1HSD17B2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | GRIA1, GRIN1, GLRA1 | HSD17B1 1172/4885HSD17B2 1612/4885POLB 4418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.