Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13618880 | 0.99 | HSD17B1 (0.43) | HSD17B1HSD17B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13618878 | 0.84 | HSD17B1 (0.52) | HSD17B1HSD17B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13618876 | 0.84 | HSD17B1 (0.49) | HSD17B1HSD17B2ACKR3MEN1ALDH1A1 | |
| SCHEMBL13618885 | 0.82 | HSD17B1 (0.48) | HSD17B1HSD17B2ACKR3MEN1ALDH1A1 | |
| SCHEMBL13618886 | 0.82 | HSD17B1 (0.50) | HSD17B1HSD17B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13618890 | 0.82 | NPC1 (0.42) | TAS1R3TAS1R1TAS1R2MEN1ALDH1A1 | |
| SCHEMBL13618871 | 0.80 | TAS1R3 (0.36) | TAS1R3TAS1R1TAS1R2ACKR3MEN1 | |
| SCHEMBL13618899 | 0.80 | HSD17B1 (0.48) | HSD17B1HSD17B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL16462590 | 0.80 | ALDH1A1 (0.56) | HSD17B1HSD17B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13618879 | 0.79 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2ACKR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286765-A1 | Therapeutic Agents | GRIA1, GRIN1, GLRA1 | HSD17B1 1172/4885HSD17B2 1612/4885TAS1R3 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.