Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681031 | 0.85 | MEN1 (0.54) | RAPGEF4MEN1POLBKMT2AGAA | |
| SCHEMBL257705 | 0.82 | LMNA (0.44) | GAAMCL1TP53ALDH1A1PDK1 | |
| SCHEMBL1679559 | 0.81 | RAPGEF4 (0.52) | RAPGEF4MEN1POLBKMT2AGAA | |
| SCHEMBL12847254 | 0.79 | MCL1 (0.50) | RAPGEF4MEN1POLBKMT2AGAA | |
| Hydrochloric Acid SCHEMBL28204647 | 0.79 | RAPGEF4 (0.50) | RAPGEF4MEN1POLBKMT2AGAA | |
| SCHEMBL13362224 | 0.74 | KMT2A (0.45) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL11791959 | 0.72 | ALDH1A1 (0.48) | RAPGEF4MEN1POLBKMT2AGAA | |
| SCHEMBL20984437 | 0.72 | GAA (0.58) | MEN1POLBKMT2AGAAHCRTR1 | |
| SCHEMBL1132624 | 0.71 | IDO1 (0.57) | RAPGEF4MEN1POLBKMT2AMCL1 | |
| SCHEMBL18800431 | 0.71 | LMNA (0.43) | MEN1KMT2AALDH1A1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140342-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2009-11-19 | — | — | WO | disclosed |