Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539681 | 0.84 | LMNA (0.51) | LMNAPOLBALDH1A1HDAC2HDAC8 | |
| SCHEMBL13397452 | 0.82 | CYP1A2 (0.53) | LMNAPOLBALDH1A1MAPK1CYP1A2 | |
| SCHEMBL9625733 | 0.82 | EPHX2 (0.51) | LMNAPOLBALDH1A1MAPK1CYP1A2 | |
| SCHEMBL12144101 | 0.82 | NPC1 (0.57) | POLBALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL12144080 | 0.82 | LMNA (0.69) | LMNAPOLBALDH1A1HDAC6TSHR | |
| SCHEMBL28007671 | 0.81 | LMNA (0.62) | LMNAPOLBHDAC2HDAC8HDAC6 | |
| SCHEMBL6539725 | 0.79 | POLB (0.62) | LMNAPOLBALDH1A1TSHRMEN1 | |
| SCHEMBL6972889 | 0.79 | LMNA (0.42) | LMNAPOLBALDH1A1HDAC2HDAC8 | |
| SCHEMBL14232503 | 0.78 | RAB9A (0.43) | LMNAPOLBALDH1A1HDAC2HDAC8 | |
| SCHEMBL16907858 | 0.75 | HPGD (0.66) | ALDH1A1HDAC6MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140342-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2009-11-19 | — | — | WO | disclosed |