Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604058 | 0.75 | KDM4E (0.33) | KDM4E | |
| SCHEMBL12650343 | 0.75 | — | — | |
| SCHEMBL545249 | 0.68 | KDM4E (0.50) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL2750457 | 0.68 | TGFBR1 (0.51) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4151566 | 0.65 | HTR6 (0.31) | KDM4EALDH1A1 | |
| SCHEMBL16478033 | 0.64 | PIK3CG (0.50) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL3132802 | 0.64 | KDM4E (0.39) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL12761243 | 0.64 | HSD17B10 (0.39) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL21097673 | 0.63 | KDM4E (0.36) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL20048908 | 0.63 | CSNK1A1 (0.45) | KDM4EALDH1A1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143477-A1 | HETEROCYCLES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2009-11-26 | — | — | WO | disclosed |