Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845548 | 0.90 | TRIM58 (0.40) | KDM1AMCHR1ADRA2ANPY5RPIM1 | |
| SCHEMBL3845553 | 0.90 | TRIM58 (0.40) | KDM1AMCHR1ADRA2ANPY5RPIM1 | |
| SCHEMBL13620414 | 0.88 | USP1 (0.35) | GRIN1GRIN2BKDM1AMCHR1ADRA2A | |
| SCHEMBL13620048 | 0.87 | USP1 (0.38) | KDM1AUSP1BRD4 | |
| SCHEMBL13620376 | 0.87 | KDM1A (0.42) | GRIN1GRIN2BKDM1ACHEK1PIM1 | |
| SCHEMBL13620412 | 0.87 | KDM1A (0.39) | KDM1AMCHR1ADRA2ANPY5RUSP1 | |
| SCHEMBL13620483 | 0.87 | KDM1A (0.47) | KDM1ACHEK1USP1 | |
| SCHEMBL13620230 | 0.86 | BRD4 (0.37) | KDM1ACHEK1MCHR1ADRA2ANPY5R | |
| SCHEMBL3848468 | 0.86 | MCHR1 (0.42) | KDM1AMCHR1ADRA2ANPY5RPRKCQ | |
| SCHEMBL13620423 | 0.86 | USP1 (0.38) | GRIN1GRIN2BKDM1ACHEK1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | GRIN1 554/4885GRIN2B 953/4885KDM1A 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.