Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.34 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | USP1 | O94782 | 4/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620230 | 0.89 | BRD4 (0.37) | ADORA2AADORA1BRD4USP1PIM1 | |
| SCHEMBL13620494 | 0.89 | USP1 (0.35) | USP1HSD17B13 | |
| SCHEMBL13620381 | 0.88 | USP1 (0.38) | BRD4USP1FLT3ATAD2DDR1 | |
| SCHEMBL13620288 | 0.88 | USP1 (0.36) | ADORA2AADORA1BRD4USP1ATAD2 | |
| SCHEMBL13620423 | 0.88 | USP1 (0.38) | ADORA2AADORA1BRD4USP1ATAD2 | |
| SCHEMBL3848468 | 0.88 | MCHR1 (0.42) | BRD4ATAD2DDR1ADRA2ANPY5R | |
| SCHEMBL3848466 | 0.88 | MCHR1 (0.42) | BRD4ATAD2DDR1ADRA2ANPY5R | |
| SCHEMBL13620229 | 0.86 | KDM1A (0.44) | ADORA2AADORA1USP1DDR1KDM1A | |
| SCHEMBL13620283 | 0.86 | CDK4 (0.34) | ADORA2AADORA1BRD4USP1FLT3 | |
| SCHEMBL13620072 | 0.86 | USP1 (0.36) | BRD4USP1ATAD2ADRA2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | ADORA2A 975/4885ADORA1 1091/4885TPH1 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.