Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PCK1 | P35558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620283 | 0.91 | CDK4 (0.34) | USP1DDR1CDK4FLT3CHEK1 | |
| SCHEMBL13620230 | 0.89 | BRD4 (0.37) | USP1DDR1CDK4FLT3CHEK1 | |
| SCHEMBL13620231 | 0.88 | ADORA2A (0.35) | USP1DDR1FLT3BRD4KDM1A | |
| SCHEMBL13620288 | 0.87 | USP1 (0.36) | USP1DDR1BRD4KDM1AATAD2 | |
| SCHEMBL3848466 | 0.87 | MCHR1 (0.42) | DDR1BRD4KDM1AATAD2 | |
| SCHEMBL3848468 | 0.87 | MCHR1 (0.42) | DDR1BRD4KDM1AATAD2 | |
| SCHEMBL13620423 | 0.87 | USP1 (0.38) | USP1DDR1CHEK1BRD4KDM1A | |
| SCHEMBL13620229 | 0.86 | KDM1A (0.44) | USP1DDR1CHEK1KDM1A | |
| SCHEMBL13620072 | 0.85 | USP1 (0.36) | USP1CCNA2CDK2CCNA1BRD4 | |
| SCHEMBL12371632 | 0.85 | PRKCQ (0.43) | USP1CHEK1BRD4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | USP1 3253/4885S1PR2 2741/4885CCNA2 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.