Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620399 | 0.91 | TRAP1 (0.47) | USP1HSP90AA1HSP90B1TRAP1KDM1A | |
| SCHEMBL13608322 | 0.89 | HSP90AA1 (0.44) | USP1HSP90AA1HSP90B1TRAP1KDM1A | |
| SCHEMBL13620423 | 0.89 | USP1 (0.38) | USP1HSP90AA1HSP90B1TRAP1KDM1A | |
| SCHEMBL13608379 | 0.89 | BRD4 (0.40) | USP1HSP90AA1HSP90B1TRAP1KDM1A | |
| SCHEMBL13620509 | 0.89 | KDM1A (0.37) | USP1HSP90AA1HSP90B1TRAP1KDM1A | |
| SCHEMBL13620429 | 0.88 | PIM1 (0.36) | KDM1ACHEK1BRD4ATAD2JAK2 | |
| SCHEMBL12371715 | 0.87 | USP1 (0.45) | USP1TNIKGRIN1GRIN2BADORA2A | |
| SCHEMBL12371698 | 0.87 | JAK2 (0.41) | USP1KDM1ABRD4ATAD2JAK2 | |
| SCHEMBL12371642 | 0.85 | CHEK1 (0.41) | KDM1ACHEK1BRD4ATAD2JAK2 | |
| SCHEMBL12371637 | 0.85 | CHEK1 (0.41) | KDM1ACHEK1BRD4ATAD2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | USP1 3253/4885HSP90AA1 3427/4885HSP90B1 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.