Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620282 | 0.90 | KDM1A (0.38) | KDM1AADORA2AADORA1BRD4ATAD2 | |
| SCHEMBL13608264 | 0.88 | KDM1A (0.39) | KDM1AMAP3K11ADORA2AADORA1BRD4 | |
| SCHEMBL13608325 | 0.86 | MTOR (0.47) | ADORA2AADORA1MTOR | |
| SCHEMBL12371670 | 0.86 | MTOR (0.47) | ADORA2AADORA1MTOR | |
| SCHEMBL13620045 | 0.86 | CAMK2D (0.38) | KDM1AMAP3K11BRD4ATAD2EHMT2 | |
| SCHEMBL13620229 | 0.84 | KDM1A (0.44) | KDM1AADORA2AADORA1JAK2JAK3 | |
| SCHEMBL13620259 | 0.83 | KDM1A (0.41) | KDM1AMAP3K11ADORA2AADORA1MTOR | |
| SCHEMBL13608202 | 0.82 | KDM1A (0.40) | KDM1ABRD4ATAD2JAK2JAK3 | |
| SCHEMBL12371725 | 0.81 | MTOR (0.49) | ADORA2AADORA1MTOR | |
| SCHEMBL13608154 | 0.81 | USP1 (0.39) | KDM1AMAP3K11ADORA2AADORA1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | KDM1A 1070/4885MAP3K11 243/4885ADORA2A 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.