Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 4/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620045 | 0.91 | CAMK2D (0.38) | TRIM58CDK4KDM1ACAMK2DBRD4 | |
| SCHEMBL3848468 | 0.88 | MCHR1 (0.42) | MCHR1DDR1ADRA2ANPY5RKDM1A | |
| SCHEMBL3848466 | 0.88 | MCHR1 (0.42) | MCHR1DDR1ADRA2ANPY5RKDM1A | |
| SCHEMBL13620423 | 0.88 | USP1 (0.38) | MCHR1DDR1ADRA2ANPY5RKDM1A | |
| SCHEMBL13620230 | 0.88 | BRD4 (0.37) | CDK4MCHR1DDR1ADRA2ANPY5R | |
| SCHEMBL13620229 | 0.87 | KDM1A (0.44) | DDR1KDM1AFASNUSP1CHEK1 | |
| SCHEMBL13620288 | 0.87 | USP1 (0.36) | MCHR1DDR1ADRA2ANPY5RKDM1A | |
| SCHEMBL13620283 | 0.86 | CDK4 (0.34) | CDK4MCHR1DDR1ADRA2ANPY5R | |
| SCHEMBL12371632 | 0.86 | PRKCQ (0.43) | MCHR1ADRA2ANPY5RKDM1ABRD4 | |
| SCHEMBL12371645 | 0.86 | PRKCQ (0.43) | MCHR1ADRA2ANPY5RKDM1ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | TRIM58 4267/4885PTK2 699/4885CDK4 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.