Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271322 | 0.88 | KDM4E (0.55) | KDM1AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL7277003 | 0.80 | HSD17B1 (0.42) | MAPTKDM4EALDH1A1POLBBLM | |
| SCHEMBL7429811 | 0.79 | MAPT (0.40) | MAPTKDM4EALDH1A1POLBBLM | |
| SCHEMBL240792 | 0.77 | TDP2 (0.41) | MAPTKDM4EPOLBCYP2C19HSD17B3 | |
| SCHEMBL7277584 | 0.77 | TDP2 (0.41) | MAPTKDM4EALDH1A1POLBBLM | |
| SCHEMBL7271740 | 0.77 | CXCR5 (0.41) | ALDH1A1TSHR | |
| SCHEMBL30758541 | 0.77 | TDP2 (0.41) | MAPTKDM4EPOLBCYP2C19HSD17B3 | |
| SCHEMBL122942 | 0.75 | HDAC9 (0.44) | — | |
| SCHEMBL7280508 | 0.75 | GRM4 (0.42) | MAPTKDM4EALDH1A1BLMTDP1 | |
| SCHEMBL29476532 | 0.75 | HDAC9 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135590-A1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2009-11-12 | — | — | WO | disclosed |