Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.42 |
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439938 | 0.95 | MAPT (0.43) | RAF1BRAFMAPTRAB9AALDH1A1 | |
| SCHEMBL13439915 | 0.89 | MAPT (0.40) | RAF1BRAFMAPTRAB9AALDH1A1 | |
| SCHEMBL13439917 | 0.88 | DGAT1 (0.47) | RAF1BRAFMAPTRAB9AALDH1A1 | |
| SCHEMBL13439916 | 0.84 | MAPT (0.40) | RAF1BRAFMAPTALDH1A1GBA1 | |
| SCHEMBL13439936 | 0.83 | IRAK4 (0.48) | RAF1BRAFMAPTALDH1A1GBA1 | |
| SCHEMBL13439747 | 0.83 | RAF1 (0.42) | RAF1BRAFMAPTRAB9AALDH1A1 | |
| SCHEMBL13439939 | 0.79 | GRM4 (0.43) | BRAFAKT1 | |
| SCHEMBL13439746 | 0.79 | NAPEPLD (0.43) | RAB9AALDH1A1SMN1; SMN2GBA1KDM4E | |
| SCHEMBL11926320 | 0.78 | GBA1 (0.45) | RAF1BRAFMAPTRAB9AALDH1A1 | |
| SCHEMBL11926323 | 0.78 | ALDH1A1 (0.43) | RAF1BRAFMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696202-B2 | IL-12 modulatory compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-13 | — | — | US | disclosed |