Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13657231 | 0.85 | PIK3CA (0.37) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4127690 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4121635 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2POLBMAPT | |
| SCHEMBL16094600 | 0.72 | PIK3CA (0.60) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL28371323 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2MTORPIK3CAPOLBKDM4E | |
| SCHEMBL1218884 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL14849909 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2PIK3CAPOLBKDM4EMAPT | |
| SCHEMBL10868875 | 0.68 | ADK (0.48) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL3984786 | 0.68 | PIK3CA (0.49) | SMN1; SMN2MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL10871103 | 0.67 | ADK (0.47) | SMN1; SMN2MTORPOLBADKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615552-B2 | Fused heterocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-11-10 | — | — | US | disclosed |