Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622706 | 0.85 | SMN1; SMN2 (0.45) | PIK3CAMTORPIK3CDPIK3CGKDM4E | |
| SCHEMBL25719399 | 0.72 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGKDM4E | |
| SCHEMBL4127690 | 0.65 | SMN1; SMN2 (0.48) | PIK3CAMTORPIK3CDPIK3CGKDM4E | |
| SCHEMBL25719380 | 0.64 | ALDH1A1 (0.50) | PIK3CAMTORKDM4EMAPTPOLB | |
| SCHEMBL25719390 | 0.64 | ALDH1A1 (0.50) | PIK3CAMTORKDM4EMAPTPOLB | |
| SCHEMBL15100272 | 0.64 | KDM4E (0.69) | KDM4EMAPTPOLBALDH1A1MAPK1 | |
| SCHEMBL4121635 | 0.63 | ALDH1A1 (0.48) | MAPTPOLBALDH1A1MAPK1HPGD | |
| SCHEMBL13622702 | 0.63 | KDM4E (0.48) | PIK3CAMTORKDM4EMAPTPOLB | |
| SCHEMBL12727108 | 0.62 | PIK3CA (0.60) | PIK3CAPIK3CDKDM4EMAPTALDH1A1 | |
| SCHEMBL14051357 | 0.61 | KDM4E (0.40) | PIK3CAPIK3CDPIK3CGKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318730-B2 | Fused hetrocyclic compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2012-11-27 | — | — | US | disclosed |
| US-20090253694-A1 | Fused hetrocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253694-A1 | Fused hetrocyclic compounds | IL2, IL15, IL4 | PIK3CA 1307/4885MTOR 2052/4885PIK3CD 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.