Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.54 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.54 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623192 | 0.86 | MEN1 (0.50) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL13622963 | 0.86 | MEN1 (0.67) | SENP1ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL10160157 | 0.85 | SENP1 (0.55) | SENP5SENP2SENP1ALDH1A1MAPT | |
| SCHEMBL1024073 | 0.84 | ALDH1A1 (0.61) | SENP5SENP2SENP1ALDH1A1MAPT | |
| SCHEMBL1024076 | 0.84 | ALDH1A1 (0.61) | SENP5SENP2SENP1ALDH1A1MAPT | |
| SCHEMBL13623066 | 0.83 | MAPT (0.50) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13623005 | 0.83 | SENP1 (0.52) | SENP5SENP2SENP1ALDH1A1LMNA | |
| SCHEMBL13670025 | 0.82 | ALDH1A1 (0.60) | SENP5SENP2SENP1ALDH1A1MAPT | |
| SCHEMBL7075396 | 0.82 | MEN1 (0.73) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL3222110 | 0.82 | SMN1; SMN2 (0.64) | ALDH1A1MAPTLMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | SENP5 2914/4885SENP2 3357/4885SENP1 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.