Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP1 | Q9P0U3 | 9/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | SENP2 | Q9HC62 | 4/20 | 0.53 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623005 | 0.89 | SENP1 (0.52) | SENP1NR1H4SENP2SENP5PRMT5 | |
| SCHEMBL10160107 | 0.86 | MAPT (0.53) | RAB9AAURKARPS6KB1HPGDHTT | |
| SCHEMBL6679114 | 0.85 | SENP1 (0.48) | SENP1NR1H4SENP2SENP5LMNA | |
| SCHEMBL13623004 | 0.85 | SENP5 (0.54) | SENP1SENP2SENP5LMNAALDH1A1 | |
| SCHEMBL30270551 | 0.85 | AURKA (0.57) | SENP1AURKARPS6KB1 | |
| SCHEMBL31710947 | 0.85 | AURKA (0.54) | SENP1SENP2SENP5PRMT5WDR77 | |
| SCHEMBL16527267 | 0.85 | AURKA (0.54) | SENP1SENP2SENP5PRMT5WDR77 | |
| SCHEMBL306845 | 0.84 | ROCK2 (0.60) | SENP1NR1H4SENP2SENP5LMNA | |
| SCHEMBL13923460 | 0.84 | PPARG (0.49) | SENP1NR1H4PRMT5WDR77LMNA | |
| SCHEMBL13853708 | 0.82 | AURKA (0.53) | LMNARAB9AAURKARPS6KB1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093266-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | SENP1 2233/4885NR1H4 2683/4885SENP2 2826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.