Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949660 | 0.89 | POLB (0.39) | KMT2AMAPTCYP1A2CYP2C9POLB | |
| SCHEMBL14949661 | 0.89 | POLB (0.39) | KMT2AMAPTCYP1A2CYP2C9POLB | |
| SCHEMBL12892585 | 0.88 | MAPT (0.46) | NPC1RAB9ATGM2TP53MAPT | |
| SCHEMBL1259837 | 0.81 | NR3C1 (0.36) | KMT2ATP53POLBLMNA | |
| SCHEMBL1259841 | 0.81 | NR3C1 (0.36) | KMT2ATP53POLBLMNA | |
| SCHEMBL4312914 | 0.77 | POLB (0.49) | KMT2AMAPTF2PRSS1PRSS2 | |
| SCHEMBL14949662 | 0.77 | POLB (0.49) | KMT2AMAPTF2PRSS1PRSS2 | |
| SCHEMBL14949654 | 0.76 | POLB (0.42) | KMT2ATP53MAPTPOLB | |
| SCHEMBL14949653 | 0.76 | POLB (0.42) | KMT2ATP53MAPTPOLB | |
| SCHEMBL1258097 | 0.75 | NR3C1 (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |