Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.33 |
| ▸ | TUBB | P07437 | 4/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999937 | 0.88 | PARP1 (0.33) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL8998407 | 0.87 | ALOX5AP (0.35) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL8999980 | 0.85 | OPRD1 (0.36) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8999788 | 0.84 | PARP1 (0.31) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL8999830 | 0.84 | MAPK7 (0.33) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL8998944 | 0.83 | ABL1 (0.46) | LMNAHIF1AMAPK1ALDH1A1ABL1 | |
| SCHEMBL8999831 | 0.82 | OGA (0.36) | — | |
| SCHEMBL10046861 | 0.82 | TUBB4A (0.41) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL10046854 | 0.82 | TUBB4A (0.38) | LMNAHIF1AMAPK1TUBB4ATUBB | |
| SCHEMBL8999551 | 0.82 | ALDH1A1 (0.35) | HTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618974-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618974-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-17 | — | — | US | disclosed |