Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10976768 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29500473 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL2867085 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1939849 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL4298094 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29401923 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28539693 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1734 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122068011-A | Preparation method of low-cost and good-stability silylene composite ferromanganese lithium nickel cobalt manganese battery electrode material | 广东明煜能源科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260022012-A1 | METHOD FOR CATALYTICALLY DRY REFORMING METHANE | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2026-01-22 | — | — | US | claimed |
| US-12485404-B2 | Process for producing an oligomerization catalyst having a hydrothermal treatment step | EVONIK OXENO GMBH & CO. KG (DE) | 2025-12-02 | — | — | US | claimed |
| US-12478954-B2 | Reforming catalyst | TOPSOE A/S (DK) | 2025-11-25 | — | — | US | claimed |
| US-20250353741-A1 | HYDROGEN PRODUCTION BY STEAM REFORMING OF DODECANE USING NICKEL-RED MUD CATALYST | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-11-20 | — | — | US | claimed |
| US-20250353742-A1 | HYDROGEN PRODUCTION VIA STEAM REFORMING OVER RED-MUD SUPPORTED NICKEL CATALYST AND METHODS OF PREPARATION THEREOF | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-11-20 | — | — | US | claimed |
| US-20250345778-A1 | HYDROGEN GAS FORMATION WITHOUT CARBON OXIDE CONTENT | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-11-13 | — | — | US | claimed |
| US-20250340433-A1 | RUTHENIUM-DOPED ALUMINA-SUPPORTED COBALT/NICKEL CATALYST FOR AMMONIA DECOMPOSITION TO HYDROGEN AND NITROGEN | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-11-06 | — | — | US | claimed |
| US-12428744-B2 | Nickel electroplating compositions for rough nickel | ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) | 2025-09-30 | — | — | US | claimed |
| US-20250281910-A1 | FIBROUS SILICA LANTHANUM OXIDE-BASED CATALYST FOR DRY REFORMING OF METHANE AND METHODS OF PREPARATION THEREOF | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-09-11 | — | — | US | claimed |
| EP-0604204-A2 | Poly(arylene sulfide) resin composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1994-06-29 | — | — | EP | claimed |
| US-4659644-A | Diazo-type thermosensitive recording material with hydrazone coupler and chelating metal compound | RICOH COMPANY, LTD. (JP) | 1987-04-21 | — | — | US | claimed |
| EP-0020940-B1 | PROCESS FOR PRODUCING AN ALKALI METAL HYDROXIDE BY ELECTROLYSING AN AQUEOUS SOLUTION OF AN ALKALI METAL CHLORIDE | ASAHI GLASS COMPANY LTD. (JP) | 1984-10-24 | — | — | EP | claimed |
| US-4473447-A | Method of manufacturing absorption layers for solar energy systems and bath therefor | MAN MASCHINENFABRIK AUGSBURG-NURNBERG AG (DE) | 1984-09-25 | — | — | US | claimed |
| US-4297182-A | ELECTROLYSIS USING A CATHODE OF NICKEL POWDER BONDED ON A POLYMER OF TETRAFLUOROETHYLENE; LOW VOLTAGE | ASAHI GLASS COMPANY, LTD. (JP) | 1981-10-27 | — | — | US | claimed |
| EP-0020940-A1 | Process for producing an alkali metal hydroxide by electrolysing an aqueous solution of an alkali metal chloride | ASAHI GLASS COMPANY LTD. (JP) | 1981-01-07 | — | — | EP | claimed |
| US-3983086-A | Smoke retardant vinyl chloride and vinylidene chloride polymer compositions | THE B. F. GOODRICH COMPANY (US) | 1976-09-28 | — | — | US | claimed |
| US-3975359-A | NICKEL AND BISMUTH COMPOUNDS | THE B. F. GOODRICH COMPANY (US) | 1976-08-17 | — | — | US | claimed |
| US-3962177-A | NICKEL AND ALUMINUM COMPOUNDS | THE B. F. GOODRICH COMPANY (US) | 1976-06-08 | — | — | US | claimed |
| US-3933742-A | NICKEL COMPOUND AND ZINC COMPOUND | THE B. F. GOODRICH COMPANY (US) | 1976-01-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260022012-A1 | METHOD FOR CATALYTICALLY DRY REFORMING METHANE | RNF4, SOD1, HRH4 | CA4 51/4885ALDH1A1 4826/4885CASP1 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.