Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5471628 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL445486 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL136236 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL379041 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569386 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL7519368 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL4298094 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569395 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL378980 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5077427 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2979760-B1 | HYDROGENATION DESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROGENATION TREATMENT METHOD FOR DIESEL OIL | COSMO OIL CO LTD (JP) | 2019-05-01 | — | — | EP | disclosed |
| US-9987622-B2 | Hydrodesulfurization catalyst for diesel oil and hydrotreating method for diesel oil | COSMO OIL CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-20160059223-A1 | HYDRODESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROTREATING METHOD FOR DIESEL OIL | COSMO OIL CO., LTD. (JP) | 2016-03-03 | — | — | US | disclosed |
| EP-2979760-A1 | HYDROGENATION DESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROGENATION TREATMENT METHOD FOR DIESEL OIL | Cosmo Oil Co., Ltd. (JP) | 2016-02-03 | — | — | EP | disclosed |
| EP-1577007-B1 | HYDROTREATING CATALYST FOR GAS OIL, PROCESS FOR PRODUCING THE SAME, AND METHOD OF HYDROTREATING GAS OIL | COSMO OIL CO LTD (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1402948-B1 | CATALYST FOR HYDROGENATION TREATMENT OF GAS OIL AND METHOD FOR PREPARATION THEREOF; AND PROCESS FOR HYDROGENATION TREATMENT OF GAS OIL | COSMO OIL CO LTD (JP) | 2013-01-09 | — | — | EP | disclosed |
| EP-1733787-B1 | CATALYST FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL AND METHOD FOR PREPARATION THEREOF, AND METHOD FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL | COSMO OIL CO LTD (JP) | 2013-01-09 | — | — | EP | disclosed |
| US-7737071-B2 | Catalyst for hydrotreating hydrocarbon oil, process for producing the same, and method for hydrotreating hydrocarbon oil | COSMO OIL CO., LTD. (JP) | 2010-06-15 | — | — | US | disclosed |
| US-7618916-B2 | Hydrotreating catalyst for gas oil, process for producing the same, and method of hydrotreating gas oil | COSMO OIL CO., LTD. (JP) | 2009-11-17 | — | — | US | disclosed |
| US-7361624-B2 | Catalyst for hydrotreating gas oil, process for producing the same, and method for hydrotreating gas oil | COSMO OIL CO., LTD. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-20080017551-A1 | Catalyst for Hydrotreating Hydrocarbon Oil, Process for Producing the Same, and Method for Hydrotreating Hydrocarbon Oil | COSMO OIL., LTD. (JP) | 2008-01-24 | — | — | US | disclosed |
| EP-1852474-A2 | Carbon black compositions and their applications | Timcal S.A. (CH) | 2007-11-07 | — | — | EP | disclosed |
| EP-1567602-B1 | CARBON BLACK COMPOSITIONS AND THEIR APPLICATIONS | TIMCAL SA (CH) | 2007-08-15 | — | — | EP | disclosed |
| EP-1733787-A1 | CATALYST FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL AND METHOD FOR PREPARATION THEREOF, AND METHOD FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL | COSMO OIL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
| US-20060116443-A1 | Metal coated carbon black, carbon black compositions and their applications | TIMCAL S.A. (CH) | 2006-06-01 | — | — | US | disclosed |
| US-20060054536-A1 | Hydrotreating catalyst for gas oil, process for producing the same, and method of hydrotreating gas oil | COSMO OIL CO., LTD. (JP) | 2006-03-16 | — | — | US | disclosed |
| EP-1577007-A1 | HYDROTREATING CATALYST FOR GAS OIL, PROCESS FOR PRODUCING THE SAME, AND METHOD OF HYDROTREATING GAS OIL | COSMO OIL CO., LTD. (JP) | 2005-09-21 | — | — | EP | disclosed |
| EP-1402948-A1 | CATALYST FOR HYDROGENATION TREATMENT OF GAS OIL AND METHOD FOR PREPARATION THEREOF, AND PROCESS FOR HYDROGENATION TREATMENT OF GAS OIL | COSMO OIL CO., LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-20030173256-A1 | Catalyst for hydrogenation treatment of gas oil and method for preparation thereof, and process for hydrogenation treatment of gas oil | COSMO OIL CO., LTD. (JP) | 2003-09-18 | — | — | US | disclosed |