Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 8/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692598 | 0.93 | HDAC4 (0.41) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL277647 | 0.92 | SIRT2 (0.45) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL13339490 | 0.87 | SIRT2 (0.41) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL12389311 | 0.85 | SIRT2 (0.42) | SIRT2SIRT1AKT1SIRT3CPB1 | |
| SCHEMBL12692606 | 0.85 | SIRT2 (0.36) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL277489 | 0.84 | SIRT2 (0.41) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL12230361 | 0.84 | SIRT2 (0.39) | SIRT2SIRT1GLP1RAKT1SIRT3 | |
| SCHEMBL11964062 | 0.83 | AKT1 (0.42) | SIRT2SIRT1GLP1RAKT1SIRT3 | |
| SCHEMBL13531987 | 0.83 | SIRT2 (0.41) | SIRT2HDAC4SIRT1EP300MEF2D | |
| SCHEMBL12148796 | 0.82 | AKT1 (0.51) | SIRT2GLP1RAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090005297-A1 | Aprotinin Variants | BAYER HEALTHCARE AG (DE) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | ADCYAP1R1, VIPR2, ADCY2 | SIRT2 260/4885HDAC4 504/4885SIRT1 429/4885 |
| US-20090005297-A1 | Aprotinin Variants | PRSS1, SPINT2, SERPINB1 | SIRT2 3050/4885HDAC4 2366/4885SIRT1 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.