ADCY2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL117280	0.79	16/20
SCHEMBL117298	0.79	16/20
SCHEMBL2657749	0.81	8/20
SCHEMBL2658383	0.63	8/20
SCHEMBL2657546	0.61	8/20
SCHEMBL2657983	0.60	8/20
SCHEMBL2657082	0.74	7/20
SCHEMBL2657077	0.60	7/20
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2654576	0.51	7/20
SCHEMBL2655409	0.51	7/20
SCHEMBL2655997	0.49	7/20
SCHEMBL2656673	0.49	7/20
SCHEMBL2657984	0.64	6/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL2657305	0.52	6/20
SCHEMBL2656182	0.52	6/20
SCHEMBL2655986	0.50	6/20

Clinical trials — most relevant to ADCY2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Carbidopa-levodopa in Neovascular AMD	PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Genetic Studies in Patients and Families With Infantile Spasms	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADCY2 binder may also engage these)

Protein	Name	Similarity
Q80TL1	—	1.000	Q80TL1 →
P26769	—	1.000	P26769 →
P32870	—	1.000	P32870 →
ADCY3	Adenylate cyclase type 3	0.999	landscape →
P40146	—	0.999	P40146 →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.998	landscape →
Q91WF3	—	0.998	Q91WF3 →
P51829	—	0.997	P51829 →
ADCY8	Adenylate cyclase type 8	0.997	landscape →
Q29450	—	0.996	Q29450 →
P97490	—	0.996	P97490 →
P21932	—	0.994	P21932 →
Q8VHH7	—	0.994	Q8VHH7 →
ADCY4	Adenylate cyclase type 4 (EC 4.6.1.1) (ATP py	0.993	landscape →
P30804	—	0.993	P30804 →
ABCC8	ATP-binding cassette sub-family C member 8	0.992	landscape →
P19754	—	0.992	P19754 →
Q09429	—	0.992	Q09429 →
Q9VK50	—	0.992	Q9VK50 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.992	landscape →
P26770	—	0.992	P26770 →
ADCY1	Adenylate cyclase type 1	0.991	landscape →
Q09427	—	0.990	Q09427 →
Q9DGG6	—	0.990	Q9DGG6 →
Q9QUQ5	—	0.990	Q9QUQ5 →
Q38998	—	0.990	Q38998 →
O88444	—	0.990	O88444 →
Q3UWA6	—	0.990	Q3UWA6 →
O95759	—	0.989	O95759 →
TRPC1	Short transient receptor potential channel 1	0.989	landscape →