Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223382 | 0.93 | CCR2 (0.51) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL12594335 | 0.91 | CCR2 (0.57) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL14620145 | 0.90 | CCR2 (0.42) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL306536 | 0.86 | CCR2 (0.60) | CCR2CYP3A4CYP2C9 | |
| SCHEMBL307457 | 0.85 | CCR2 (0.59) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL10223322 | 0.85 | CCR2 (0.59) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL29888391 | 0.85 | CCR2 (0.59) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL10272179 | 0.83 | CCR2 (0.55) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL12594657 | 0.83 | CCR2 (0.56) | ALDH1A1LMNAHTTCCR2CYP3A4 | |
| SCHEMBL13624507 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTCCR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |