Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365235 | 0.90 | CHRM3 (0.40) | DRD4CHRM3DRD2CHRM2CHRM1 | |
| SCHEMBL3411496 | 0.90 | CHRM3 (0.40) | DRD4CHRM3DRD2CHRM2CHRM1 | |
| SCHEMBL1362605 | 0.90 | LOXL2 (0.40) | FAAHPRMT6CFDHTR1ADRD2 | |
| SCHEMBL1632732 | 0.89 | SLC2A1 (0.38) | FAAHDRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL1632745 | 0.87 | KLK1 (0.40) | NCF1CFDKLKB1KLK1CHRM3 | |
| SCHEMBL1631726 | 0.87 | CYP2E1 (0.40) | FAAHKLKB1KLK1KDM4EALDH1A1 | |
| SCHEMBL1633737 | 0.86 | KLKB1 (0.39) | CFDKLKB1KLK1CHRM3PARP1 | |
| SCHEMBL1632683 | 0.84 | KDM4E (0.48) | FAAHDRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL1631046 | 0.82 | DPP4 (0.39) | FAAHCHRM3CHRM2CHRM1 | |
| SCHEMBL1363928 | 0.79 | CHRM3 (0.39) | FAAHDRD4CHRM3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |