Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 3/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | USP19 | O94966 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362390 | 0.86 | FAAH (0.41) | KLKB1KLK1CHRM3CFDPARP1 | |
| SCHEMBL1362605 | 0.85 | LOXL2 (0.40) | CFDWNK1USP19CNR2 | |
| SCHEMBL1632745 | 0.81 | KLK1 (0.40) | KLKB1KLK1CHRM3CFDCYP3A4 | |
| SCHEMBL1365235 | 0.79 | CHRM3 (0.40) | CHRM3 | |
| SCHEMBL3411496 | 0.79 | CHRM3 (0.40) | CHRM3 | |
| SCHEMBL1632056 | 0.78 | FAAH (0.48) | CHRM3 | |
| SCHEMBL1631726 | 0.77 | CYP2E1 (0.40) | KLKB1KLK1CHRM3CYP3A4CYP2C9 | |
| SCHEMBL1632732 | 0.76 | SLC2A1 (0.38) | CHRM3 | |
| SCHEMBL4052726 | 0.76 | CHRM3 (0.45) | KLKB1KLK1CHRM3CFDKARS1 | |
| SCHEMBL1363928 | 0.74 | CHRM3 (0.39) | CHRM3WNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932247-B2 | M3 muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2011-04-26 | — | — | US | disclosed |