Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362605 | 0.86 | LOXL2 (0.40) | FAAHWNK1DRD2KDM4AKDM4C | |
| SCHEMBL1631046 | 0.79 | DPP4 (0.39) | CHRM3SLC2A1FAAHCHRM4 | |
| SCHEMBL1362390 | 0.79 | FAAH (0.41) | CHRM3FAAHDRD4DRD2HTR1A | |
| SCHEMBL3398494 | 0.77 | MLNR (0.43) | CHRM3FAAHCHRM4USP30 | |
| SCHEMBL1632683 | 0.75 | KDM4E (0.48) | FAAHNTRK1DRD4 | |
| SCHEMBL1633737 | 0.74 | KLKB1 (0.39) | CHRM3WNK1 | |
| SCHEMBL2769119 | 0.73 | MLNR (0.63) | CHRM3FAAHCHRM4DRD4 | |
| SCHEMBL1631726 | 0.73 | CYP2E1 (0.40) | CHRM3FAAH | |
| SCHEMBL1363926 | 0.73 | CHRM2 (0.40) | CHRM3CHRM4GPR6USP30 | |
| SCHEMBL1632732 | 0.73 | SLC2A1 (0.38) | CHRM3SLC2A1FAAHDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |