Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624663 | 0.88 | MAPK10 (0.49) | MAPK10MAPK8HPGDNR3C1PGR | |
| SCHEMBL13624505 | 0.83 | MAPK10 (0.55) | MAPK10MAPK8SMOMAPK13MAPK12 | |
| SCHEMBL121319 | 0.82 | MAPK10 (0.55) | MAPK10MAPK8HPGDNR3C1CYP11B1 | |
| SCHEMBL19533612 | 0.81 | MGLL (0.55) | MAPK10MAPK8HPGDNR3C1MAOB | |
| SCHEMBL13623919 | 0.80 | MAPK10 (0.67) | MAPK10MAPK8SMOMAPK13MAPK12 | |
| SCHEMBL13624666 | 0.80 | NR3C1 (0.49) | MAPK10MAPK8NR3C1SMOMAPK13 | |
| SCHEMBL13624667 | 0.79 | MAPK10 (0.51) | MAPK10MAPK8NR3C1PGRSMO | |
| SCHEMBL13617492 | 0.79 | SMO (0.49) | MAPK10MAPK8SMO | |
| SCHEMBL13624133 | 0.77 | MAPK10 (0.54) | MAPK10MAPK8SMOMAPK13MAPK12 | |
| SCHEMBL13623929 | 0.74 | NR3C1 (0.59) | MAPK10MAPK8HPGDNR3C1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |