Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623928 | 0.88 | MAPK10 (0.48) | MAPK10MAPK8HPGDNR3C1PGR | |
| SCHEMBL836830 | 0.85 | MAPK10 (0.48) | MAPK10MAPK8HPGDMGLLSMO | |
| SCHEMBL2610311 | 0.81 | MGLL (0.57) | MAPK10MAPK8HPGDNR3C1MGLL | |
| SCHEMBL13623919 | 0.81 | MAPK10 (0.67) | MAPK10MAPK8SMO | |
| SCHEMBL6840245 | 0.80 | HPGDS (0.60) | MAPK10MAPK8HPGDNR3C1PGR | |
| SCHEMBL121760 | 0.80 | KHK (0.55) | MAPK10MAPK8HPGDNR3C1MGLL | |
| SCHEMBL13624667 | 0.80 | MAPK10 (0.51) | MAPK10MAPK8NR3C1PGRSMO | |
| SCHEMBL13624505 | 0.79 | MAPK10 (0.55) | MAPK10MAPK8SMOHPGDS | |
| SCHEMBL13624666 | 0.78 | NR3C1 (0.49) | MAPK10MAPK8NR3C1SMOHPGDS | |
| SCHEMBL13624133 | 0.78 | MAPK10 (0.54) | MAPK10MAPK8SMOHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016124722-A1 | A PROCESS FOR THE PREPARATION OF 3-5-{[(1R,2S)-2-[(2,2-DIFLUOROPROPANYL)AMINO]-1 -(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL]PROPYL]OXY}-1H-INDAZOL-1-YL)-N-[(3R)-TETRAHYDROFURAN-3-YL] BENZAMIDE | ASTRAZENECA AB (SE) | 2016-08-11 | — | — | WO | disclosed |
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |