Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23303573 | 0.87 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL26819807 | 0.87 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL12450000 | 0.86 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL26819793 | 0.85 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL19318761 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL26819797 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL17673749 | 0.85 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| Water SCHEMBL27701299 | 0.84 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL3685899 | 0.84 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA | |
| SCHEMBL26819803 | 0.84 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1TNK2PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | TEIJIN PHARMA LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | CTSE, SPINT2, CTSF | HSP90AA1 576/4885HSP90AB1 535/4885TNK2 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.