Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12347500 | 0.86 | ESR1 (0.36) | ALDH1A1MAPTPKMPSEN1PSEN2 | |
| SCHEMBL10305645 | 0.84 | POLB (0.43) | ALDH1A1MAPTTRPM8L3MBTL1HCRTR2 | |
| SCHEMBL1762506 | 0.80 | ALDH1A1 (0.37) | ALDH1A1MAPTPKMPSEN1PSEN2 | |
| SCHEMBL12347489 | 0.80 | TRPM8 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14303612 | 0.80 | TRPM8 (0.39) | ALDH1A1MAPTPKMTRPM8L3MBTL1 | |
| SCHEMBL14303174 | 0.78 | PTGDR (0.37) | ALDH1A1MAPTPSEN1PSEN2APH1B | |
| SCHEMBL12594248 | 0.76 | CCR4 (0.39) | ALDH1A1MAPTPKMPSEN1PSEN2 | |
| SCHEMBL14303635 | 0.76 | ESR1 (0.37) | ALDH1A1MAPTPKMPSEN1PSEN2 | |
| SCHEMBL306124 | 0.74 | ESR1 (0.36) | ALDH1A1MAPTPKMPSEN1PSEN2 | |
| SCHEMBL12161784 | 0.74 | POLB (0.43) | ALDH1A1MAPTTRPM8L3MBTL1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |