Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 3/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14302499 | 0.89 | TRPM8 (0.39) | TRPM8NR1I2KEAP1NFE2L2TP53 | |
| SCHEMBL306197 | 0.88 | TRPM8 (0.39) | TRPM8NR1I2KEAP1NFE2L2TP53 | |
| SCHEMBL14303174 | 0.83 | PTGDR (0.37) | NFE2L2TP53SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL12347500 | 0.82 | ESR1 (0.36) | TRPM8TP53SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL10305645 | 0.81 | POLB (0.43) | TRPM8HCRTR2 | |
| SCHEMBL14303612 | 0.80 | TRPM8 (0.39) | TRPM8TP53SMN1; SMN2MCOLN3HCRTR2 | |
| SCHEMBL13624292 | 0.80 | ALDH1A1 (0.34) | TRPM8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL308098 | 0.78 | TRPM8 (0.42) | TRPM8KEAP1NFE2L2TP53SMN1; SMN2 | |
| SCHEMBL2982116 | 0.77 | TP53 (0.43) | NR1I2KEAP1NFE2L2TP53SMN1; SMN2 | |
| SCHEMBL305602 | 0.77 | KEAP1 (0.36) | TRPM8KEAP1NFE2L2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354126-A1 | Heteroaryl sulfonamides and CCR2 | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |