Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | WDR5 | P61964 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14189203 | 0.87 | MAPT (0.57) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL8354095 | 0.87 | MAPT (0.62) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL4289177 | 0.86 | WDR5 (0.69) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL13624589 | 0.86 | MAPT (0.70) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL5211922 | 0.84 | ALDH1A1 (0.76) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL4290148 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL4284845 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL28845869 | 0.80 | MAPT (0.62) | SMN1; SMN2LMNAMAPTALDH1A1GAA | |
| SCHEMBL4254513 | 0.80 | TAAR1 (0.79) | SMN1; SMN2MAPTALDH1A1GAAMAPK1 | |
| SCHEMBL17223430 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615553-B2 | E.g., N,N-dimethyl,((5-(hydroxyaminocarbonyl)pyrimidin-2-yl)(piperazin-1,4-ylene)sulfonamide; bioavailability; oral administration; metabolic stability; side effect reduction; psoriasis; anticarcinogenic -proliferative, -arthritic, -inflammatory agent; gene therapy; genetic transcription potentiation | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-11-10 | — | — | US | disclosed |