Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15959057 | 0.92 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957557 | 0.92 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13552277 | 0.92 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957558 | 0.92 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13624883 | 0.89 | HSD11B1 (0.75) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13624884 | 0.88 | HSD11B1 (0.75) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL14865082 | 0.86 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL735514 | 0.85 | HSD11B1 (0.62) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15959055 | 0.85 | CYP2C19 (0.72) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15241449 | 0.84 | HSD11B1 (0.86) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300461-B1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |