Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116840 | 0.90 | CNR1 (0.35) | CNR1LMNACYP3A4CHRM2HTR1A | |
| SCHEMBL116841 | 0.90 | CNR1 (0.35) | CNR1LMNACYP3A4CHRM2HTR1A | |
| SCHEMBL13552217 | 0.90 | HTR1A (0.37) | CNR1LMNACYP3A4CHRM2HTR1A | |
| SCHEMBL13552219 | 0.77 | CYP3A4 (0.32) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL117417 | 0.75 | SMN1; SMN2 (0.40) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL13953706 | 0.69 | CYP3A4 (0.38) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL3192627 | 0.68 | SIGMAR1 (0.39) | CNR1LMNACYP3A4CHRM2HTR1A | |
| SCHEMBL2698655 | 0.67 | SMN1; SMN2 (0.33) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL734950 | 0.67 | SMN1; SMN2 (0.33) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL1902599 | 0.65 | SMN1; SMN2 (0.43) | LMNACYP3A4CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |