Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 19/20 | 0.85 |
| ▸ | CTSS | P25774 | 19/20 | 0.85 |
| ▸ | CTSK | P43235 | 19/20 | 0.85 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347004 | 0.92 | CTSB (1.00) | CTSBCTSSCTSK | |
| SCHEMBL8223853 | 0.88 | CTSS (0.79) | CTSBCTSSCTSKRIPK1 | |
| SCHEMBL13624901 | 0.81 | CTSB (0.57) | CTSBCTSSCTSK | |
| SCHEMBL13624899 | 0.81 | CTSB (0.69) | CTSBCTSSCTSK | |
| SCHEMBL11889903 | 0.80 | CTSB (0.79) | CTSBCTSSCTSK | |
| SCHEMBL12237638 | 0.78 | CTSB (0.63) | CTSBCTSSCTSK | |
| SCHEMBL10188181 | 0.76 | CTSB (0.85) | CTSBCTSSCTSK | |
| SCHEMBL10187741 | 0.76 | CTSB (0.85) | CTSBCTSSCTSK | |
| SCHEMBL347356 | 0.75 | CTSB (0.73) | CTSBCTSSCTSK | |
| SCHEMBL10188182 | 0.73 | CTSB (0.80) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CTSB 31/4885CTSS 24/4885CTSK 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.