Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624997 | 0.90 | KDM4E (0.61) | GAAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL463008 | 0.79 | CYP1A2 (0.57) | CYP1A2GAAKDM4EMAPTL3MBTL1 | |
| SCHEMBL9232310 | 0.76 | KDM4E (0.64) | GAAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8523769 | 0.72 | KDM4E (0.62) | GAAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL13895390 | 0.70 | MEN1 (0.57) | KDM4EMEN1KMT2ALMNAHPGD | |
| SCHEMBL9748781 | 0.69 | KDM4E (0.68) | CYP1A2GAAKDM4EMAPTMEN1 | |
| SCHEMBL9387187 | 0.68 | KDM4E (0.69) | GAAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL2561294 | 0.68 | KDM4E (0.67) | GAAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL17161708 | 0.68 | MEN1 (0.62) | KDM4EMEN1KMT2ALMNAHPGD | |
| SCHEMBL8474173 | 0.68 | BCHE (0.66) | GAAKDM4EMAPTHTTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612082-B2 | Treating glaucoma; eye disorders | ALLERGAN, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612082-B2 | Treating glaucoma; eye disorders | ALLERGAN, INC. (US) | 2009-11-03 | — | — | US | disclosed |