Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232310 | 0.88 | KDM4E (0.64) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9748781 | 0.87 | KDM4E (0.68) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9387187 | 0.86 | KDM4E (0.69) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL8474173 | 0.83 | BCHE (0.66) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9747358 | 0.83 | KDM4E (0.63) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9384234 | 0.82 | KDM4E (0.72) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9382159 | 0.82 | KDM4E (0.65) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL27524922 | 0.81 | BCHE (0.63) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL13624997 | 0.81 | KDM4E (0.61) | KDM4EBCHEHTTGAAACHE | |
| SCHEMBL9748588 | 0.81 | KDM4E (0.66) | KDM4EBCHEHTTGAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861411-A | TREATING DISTURBANCES OF MEMORY SUCH AS SENILE DEMENTIA AND ALZHEIMER'S DISEASE | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-01-19 | — | — | US | disclosed |
| US-5536728-A | TREATMENT OF SENILE DEMENTIA AND ALZHEIMER'S DISEASE | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-07-16 | — | — | US | disclosed |
| EP-0427636-B1 | 4-Acylaminopyridine derivatives | MITSUBISHI CHEM CORP (JP) | 1996-05-29 | — | — | EP | disclosed |
| US-5397785-A | Activators of cholinergic neurons to treat memory disorders such as senile dementia and Alzheimer's disease | MITSUBISHI KASEI CORPORATION (JP) | 1995-03-14 | — | — | US | disclosed |
| EP-0319429-B1 | 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient | MITSUBISHI CHEM IND (JP) | 1994-04-27 | — | — | EP | disclosed |
| EP-0427636-A2 | 4-Acylaminopyridine derivatives | Mitsubishi Chemical Corporation (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4985430-A | ALZHEIMER*S DISEASE | MITSUBISHI KASEI CORPORATION (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0319429-A2 | 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient | MITSUBISHI KASEI CORPORATION (JP) | 1989-06-07 | — | — | EP | disclosed |