Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | MC5R | P33032 | 3/20 | 0.46 |
| ▸ | MC3R | P41968 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231275 | 0.81 | MC4R (0.59) | SMN1; SMN2POLBSLC6A4MAPTALDH1A1 | |
| SCHEMBL13131708 | 0.81 | REN (0.58) | SMN1; SMN2REN | |
| SCHEMBL13617898 | 0.76 | REN (0.54) | SLC6A4SLC6A2RENCYP2D6KCNH2 | |
| SCHEMBL13625506 | 0.75 | REN (0.56) | SLC6A4SLC6A2RENKCNH2 | |
| SCHEMBL1082318 | 0.75 | CDK9 (0.45) | SMN1; SMN2MAPTALDH1A1LMNAMTNR1A | |
| SCHEMBL13625485 | 0.74 | REN (0.49) | SMN1; SMN2SLC6A4SLC6A2MAPTTP53 | |
| SCHEMBL13625590 | 0.74 | REN (0.45) | SLC6A4SLC6A2RENCYP2D6KCNH2 | |
| SCHEMBL13625505 | 0.74 | REN (0.59) | RENKCNH2 | |
| SCHEMBL13625495 | 0.73 | SLC6A2 (0.60) | SLC6A4SLC6A2RENCYP2D6KCNH2 | |
| SCHEMBL13625586 | 0.73 | REN (0.62) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |