Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.34 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.34 |
| ▸ | RPS17 | P08708 | 1/20 | 0.34 |
| ▸ | RPSA | P08865 | 1/20 | 0.34 |
| ▸ | RPS2 | P15880 | 1/20 | 0.34 |
| ▸ | RPL35A | P18077 | 1/20 | 0.34 |
| ▸ | RPL7 | P18124 | 1/20 | 0.34 |
| ▸ | RPL17 | P18621 | 1/20 | 0.34 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.34 |
| ▸ | RPS3 | P23396 | 1/20 | 0.34 |
| ▸ | RPS12 | P25398 | 1/20 | 0.34 |
| ▸ | RPL13 | P26373 | 1/20 | 0.34 |
| ▸ | RPL10 | P27635 | 1/20 | 0.34 |
| ▸ | RPL12 | P30050 | 1/20 | 0.34 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625587 | 0.88 | REN (0.65) | RENKCNH2CYP3A4 | |
| SCHEMBL13625584 | 0.84 | REN (0.56) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL13625505 | 0.75 | REN (0.59) | RENKCNH2CYP3A4 | |
| SCHEMBL13625586 | 0.74 | REN (0.62) | RENKCNH2CYP3A4 | |
| SCHEMBL13625495 | 0.74 | SLC6A2 (0.60) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL13625497 | 0.74 | REN (0.48) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL13625590 | 0.72 | REN (0.45) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL4315557 | 0.72 | REN (0.45) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL13625506 | 0.71 | REN (0.56) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL6880357 | 0.69 | REN (0.82) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |